Video: What are the health implications of TB case?

updated 5/30/2007 8:21:37 PM ET 2007-05-31T00:21:37

A man with a form of tuberculosis so dangerous he is under the first U.S. government-ordered quarantine since 1963 had health officials around the world scrambling Wednesday to find about 80 passengers who sat within five rows of him on two trans-Atlantic flights.

The man told a newspaper he took the first flight from Atlanta to Europe for his wedding, then the second flight home because he feared he might die without treatment in the U.S.

Centers for Disease Control and Prevention Director Julie Gerberding said Wednesday that the CDC is working closely with airlines to find passengers who may have been exposed to the rare, dangerous strain. Health officials in France said they have asked Air France-KLM for passenger lists, and the Italian Health Ministry said it is tracing the man’s movements.

“Is the patient himself highly infectious? Fortunately, in this case, he’s probably not,” Gerberding said. “But the other piece is this bacteria is a very deadly bacteria. We just have to err on the side of caution.”

Dr. Martin Cetron, director of the CDC’s division of global migration and quarantine, said Wednesday that the agency was trying to contact 27 crew members from the two flights for testing and about 80 passengers who sat in the five rows surrounding the man. About 40 or 50 of those people sat in or near Row 51 on the Air France flight from Atlanta to Paris, and about 30 passengers were in or near seat 12C on the second flight, from Prague to Montreal.

Health officials said the man had been advised not to fly and knew he could expose others when he boarded the jets.

The man, however, told The Atlanta Journal-Constitution that doctors didn’t order him not to fly and only suggested he put off his long-planned wedding in Greece. He knew he had a form of tuberculosis and that it was resistant to first-line drugs, but he didn’t realize until he was already in Europe that it could be so dangerous, he said.

“We headed off to Greece thinking everything’s fine,” said the man, who declined to be identified because of the stigma attached to his diagnosis.

He flew to Paris on May 12 aboard Air France Flight 385, also listed as Delta Air Lines codeshare Flight 8517. While he was in Europe, health authorities reached him with the news that further tests had revealed his TB was a rare, “extensively drug-resistant” form, far more dangerous than he knew. They ordered him into isolation, saying he should turn himself over to Italian officials.

Instead, the man flew from Prague to Montreal on May 24 aboard Czech Air Flight 0104, then drove into the United States at Champlain, N.Y. He told the newspaper he was afraid that if he didn’t get back to the U.S., he wouldn’t get the treatment he needed to survive.

He is now at Atlanta’s Grady Memorial Hospital in respiratory isolation.

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Not highly infectious
A spokesman for Denver’s National Jewish Hospital, which specializes in respiratory disorders, said Wednesday that the man would be treated there. It was not clear when he would arrive, spokesman William Allstetter said.

“The patient continues to feel well and be asymptomatic. He’s currently still in isolation,” Cetron said Wednesday. Citing privacy concerns, he said the CDC “cannot and won’t talk further about this patient.”

The other passengers on the flights are not considered at high risk of infection because tests indicated the amount of TB bacteria in the man was low, Cetron said.

But Gerberding noted that U.S. health officials have had little experience with this type of TB. It’s possible it may have different transmission patterns, she said.

“We’re thankful the patient was not in a highly infectious state, but we know the risk of transmission isn’t zero, even with the fact that he didn’t have symptoms and didn’t appear to be coughing,” Gerberding said on ABC’s “Good Morning America.”

“We’ve got to really look at the people closest to him, get them skin tested.”

Dr. Howard Njoo of the Public Health Agency of Canada said it appeared unlikely that the man spread the disease on the flight into Canada. Still the agency was working with U.S. officials to contact passengers who sat near him.

Daniela Hupakova, a spokeswoman for the Czech airline CSA, said the flight crew underwent medical checks and are fine. The airline was contacting passengers and cooperating with Czech and foreign authorities, she said. Health officials in France have asked Air France-KLM to provide lists of passengers seated within two rows of the man, an airline spokeswoman said on condition of anonymity according to company policy.

Source of infection unknown
The man told the Journal-Constitution he was in Rome during his honeymoon when the CDC notified him of the new tests and told him to turn himself in to Italian authorities to be isolated and be treated. The CDC told him he couldn’t fly aboard commercial airliners.

“I thought to myself: You’re nuts. I wasn’t going to do that. They told me I had been put on the no-fly list and my passport was flagged,” the man said.

He told the newspaper he and his wife decided to sneak back into the U.S. through Canada. He said he voluntarily went to a New York hospital, then was flown by the CDC to Atlanta.

He is not facing prosecution, health officials said.

“I’m a very well-educated, successful, intelligent person,” he told the paper. “This is insane to me that I have an armed guard outside my door when I’ve cooperated with everything other than the whole solitary-confinement-in-Italy thing.”

CDC officials told The Associated Press they could not immediately comment on the interview.

Health officials said the man’s wife tested negative for TB before the trip and is not considered a public health risk. They said they don’t know how the Georgia man was infected.

The quarantine order was the first since the government quarantined a patient with smallpox in 1963, according to the CDC.

Tuberculosis is caused by germs that are spread from person to person through the air. It usually affects the lungs and can lead to symptoms such as chest pain and coughing up blood. It kills nearly 2 million people each year worldwide.

Because of antibiotics and other measures, the TB rate in the United States has been falling for years. Last year, it hit an all-time low of 13,767 cases, or about 4.6 cases per 100,000 Americans.

Health officials worry about “multidrug-resistant” TB, which can withstand the mainline antibiotics isoniazid and rifampin. The man was infected with something even worse — “extensively drug-resistant” TB, also called XDR-TB, which resists many drugs used to treat the infection.

There have been 17 U.S. XDR-TB cases since 2000, according to CDC statistics.

© 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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