updated 4/8/2008 5:19:40 PM ET 2008-04-08T21:19:40

The Food and Drug Administration on Tuesday said more than 100 patients have died while taking the blood thinner heparin since early 2007.

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The agency found that 62 deaths are associated with contaminated batches of the blood thinner, triple the previous estimate. That doesn't mean people are still dying — the latest deaths the FDA knows of occurred in February, the month Baxter International recalled contaminated batches.

But dozens of deaths weren't reported to the agency when they happened, only later after the tainted blood thinner made headlines.

On Tuesday, the FDA posted a month-by-month mortality count on its Web site, showing a sudden jump in allergic-style fatal reactions actually began last November — possibly signaling the time when the contamination began.

The FDA's investigation found a compound derived from animal cartilage sneaked into supplies of raw heparin coming from China. Although scientists haven't yet proved the compound triggered the reactions, it is the chief suspect.

Until now, the FDA has linked the contamination to 19 deaths from allergic-style reactions. Patients who receive heparin often are so sick that it's impossible to prove the cause of death, however, and Baxter has put the death toll at four.

Tuesday's report shows the FDA has learned of 103 deaths among heparin patients since January 2007, 62 of them associated with allergic-style symptoms. The report includes deaths among users of all brands of heparin, not just Baxter's.

Allergic reactions are a rare reality with heparin, the FDA's data shows, with three such deaths reported in 2006 and a few in early 2007.

Now the FDA has reports of eight such deaths last November, 12 in December, 16 in January and 11 in February.

Heparin is derived from pig intestines and China is the world's leading supplier. Investigators have not determined where in the supply chain the contaminant was introduced.

Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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