updated 7/18/2008 12:46:32 PM ET 2008-07-18T16:46:32

Plans for a large-scale trial of a potential AIDS vaccine are being dropped in favor of a smaller, more focused study, the National Institutes of Health said.

  1. Don't miss these Health stories
    1. Splash News
      More women opting for preventive mastectomy - but should they be?

      Rates of women who are opting for preventive mastectomies, such as Angeline Jolie, have increased by an estimated 50 percent in recent years, experts say. But many doctors are puzzled because the operation doesn't carry a 100 percent guarantee, it's major surgery -- and women have other options, from a once-a-day pill to careful monitoring.

    2. Larry Page's damaged vocal cords: Treatment comes with trade-offs
    3. Report questioning salt guidelines riles heart experts
    4. CDC: 2012 was deadliest year for West Nile in US
    5. What stresses moms most? Themselves, survey says

The trial of the vaccine, developed by the Vaccine Research Center at the National Institute of Allergy and Infectious Disease, had been planned to include 2,400 men in the United States in a study called PAVE 100.

However, the agency said Thursday that it has decided that the vaccine did not warrant a trial of this size and scope. Instead NIAID said it will plan a smaller, more focused clinical trial designed to see whether the product has a significant effect on the amount of virus in a person's blood.

If an effect is found, then additional studies, or an expansion of the study could be carried out.

NIAID said it acted after reviewing the results of the STEP trial, a study of another vaccine that was halted last fall after reports of an increased number of infections among volunteers taking part in the test.

The agency said it still considers its vaccine scientifically intriguing and sufficiently different from other vaccines to proceed with the smaller trial.

Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Discuss:

Discussion comments

,

Most active discussions

  1. votes comments
  2. votes comments
  3. votes comments
  4. votes comments