updated 4/7/2009 5:16:09 PM ET 2009-04-07T21:16:09

Early trials of a new drug for advanced prostate cancer are showing some success, researchers report.

  1. Don't miss these Health stories
    1. Splash News
      More women opting for preventive mastectomy - but should they be?

      Rates of women who are opting for preventive mastectomies, such as Angeline Jolie, have increased by an estimated 50 percent in recent years, experts say. But many doctors are puzzled because the operation doesn't carry a 100 percent guarantee, it's major surgery -- and women have other options, from a once-a-day pill to careful monitoring.

    2. Larry Page's damaged vocal cords: Treatment comes with trade-offs
    3. Report questioning salt guidelines riles heart experts
    4. CDC: 2012 was deadliest year for West Nile in US
    5. What stresses moms most? Themselves, survey says

Of the first 30 patients treated with MDV3100, 13 showed declines of more than 50 percent in the levels of chemicals in the blood that indicate the presence of the cancer.

However, the tests are only in phase 1 and 2, where drugs are checked for safety, side effects and early indications of effectiveness. The drug still faces a larger phase 3 tests of effectiveness before it can be proposed for use.

The preliminary findings, by a team led by Charles L. Sawyers of Memorial Sloan-Kettering Cancer Center in New York, are reported in Friday's edition of the journal Science.

The treatment is for prostate cancer that has metastasized, or spread to other areas of the body.

Men with these cancers are often treated with drugs that inhibit the activity of male hormones, which can drive tumor growth. But tumors can become resistant to those drugs.

The new one binds to receptors for the male hormones, thus retaining the anticancer activity, the researchers report.

Copyright 2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


Discussion comments


Most active discussions

  1. votes comments
  2. votes comments
  3. votes comments
  4. votes comments