By LiveScience staff writer
updated 5/10/2010 12:42:41 PM ET 2010-05-10T16:42:41

Problem gamblers have a stronger response in the reward section of their brains to so-called "near misses" than do people who only gamble casually, a new study finds. The results might explain why gamblers have such a hard time pulling themselves away from the slots, the researchers say.

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A near miss is a situation in which a gambler appears to have fallen just short of the jackpot, such as when the spinning slot machine wheels land on two cherries and a lemon. In reality, it is no different from a regular loss.

The findings add weight to the idea that gambling targets some of the same brain systems known to play a role in chemical addictions to drugs, according to study researcher Luke Clark of the University of Cambridge. Specifically, Clark suggests near misses activate the release of dopamine, a brain chemical involved in the reward response to everything from chocolate to cocaine.

"We know that all drugs of abuse target the dopamine system and that mechanism is thought to be crucial for the addictive properties of these drugs," Clark said. "[The finding] strengthens the links between problem gambling and drug addiction."

"Almost" a win
Previously, Clark and his colleagues showed that the brain area that responds to winning also responds to these near missesin people who only gamble occasionally. They were curious to see if this response might vary depending on the severity of a person's gambling problem.

They used functional magnetic resonance imaging (fMRI) to scan the brains of 20 individuals who played a computer game simulating slot machines. During the game, participants were given the chance to win real money, but, unknown to them, the most they could win was about $23.

"Subjects who had more symptoms of problem gambling, gambling debts, family conflicts about gambling...showed a stronger response to near misses that was in a part of the brain that we know is very rich in dopamine," Clark said.

Treatment options
The results suggest certain forms of psychiatric and drug treatments might be useful for gambling problems, Clark said.

"It suggests that a form of cognitive therapy where we try and identify these beliefs about near misses and encourage the gambler to interpret these near misses in a more accurate way, that may be useful technique in psychotherapy," Clark told LiveScience.

"Drugs that target the dopamine systemand aim to dampen these dopamine responses may be effective in treating problem gambling," he said.

More research is needed to verify the dopamine response is involved in reaction to near misses, since this study only identified the brain area, not the neuro-chemicals, involved. Also, future behavioral studies done in the real world could help to confirm near misses fuel gambling habits.

The research, which was published May 5 in the Journal of Neuroscience, was supported by the Medical Research Council and the Responsible Gambling Fund, among others.

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