updated 7/12/2010 4:31:47 PM ET 2010-07-12T20:31:47

Bristol-Myers Squibb Co. said Monday it is recalling eight production lots of its anti-clotting drug Coumadin because the amount of the active ingredient in the drug could change.

  1. Don't miss these Health stories
    1. Splash News
      More women opting for preventive mastectomy - but should they be?

      Rates of women who are opting for preventive mastectomies, such as Angeline Jolie, have increased by an estimated 50 percent in recent years, experts say. But many doctors are puzzled because the operation doesn't carry a 100 percent guarantee, it's major surgery -- and women have other options, from a once-a-day pill to careful monitoring.

    2. Larry Page's damaged vocal cords: Treatment comes with trade-offs
    3. Report questioning salt guidelines riles heart experts
    4. CDC: 2012 was deadliest year for West Nile in US
    5. What stresses moms most? Themselves, survey says

The company said the recall is a precaution, and no side effects have been reported. Bristol-Myers Squibb is recalling a total of 144,672 1-milligram tablets of Coumadin, all of which were distributed in the U.S. The recall includes five production lots of Coumadin hospital unit doses and three lots of physician samples. All the tablets were distributed in blister packs. No bottled medicine or other doses are involved.

The New York-based company said the amount of isopropanol in the tablets could change over time. Isopropanol, or isopropyl alcohol, is used to keep the drug's active ingredient in a crystalline state. The changing levels of isopropanol could increase or reduce the amount of the active ingredient in the tablets.

Coumadin, also called warfarin, is a common blood thinner that is used to treat or prevent blood clots after surgery. Bristol-Myers Squibb said the risk of clots could increase if the level of active ingredient decreases, and if there is too much of the ingredient, patients face a greater risk of bleeding.

The tablets have expiration dates between June 2011 and November 2012.

Copyright 2010 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Discuss:

Discussion comments

,

Most active discussions

  1. votes comments
  2. votes comments
  3. votes comments
  4. votes comments