updated 9/11/2010 7:25:17 AM ET 2010-09-11T11:25:17

A double-decker bus carrying at least 20 people hit a railroad bridge in central New York, killing four people and injuring several others early Saturday morning, officials said.

Larry Ives, supervisor of dispatch operations for the Onondaga County Sheriff's Department, said the bus crashed on a highway in Salina, a Syracuse suburb, around 2:30 a.m. ET Saturday.

Ives said the bus was too tall to make it under the low-clearance bridge on the Onondaga Lake Parkway.

A bus company executive said the bus was off its route when it crashed but he did not know why.

Don Carmichael is a senior vice president Coach USA, which operates Megabus. He said the bus left Philadelphia at 10 p.m. ET Friday and was headed for Toronto with stops in Syracuse and Buffalo.

Ives confirmed that four people are dead and numerous others were taken to hospitals with injuries ranging from critical to minor.

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