updated 9/21/2010 8:16:20 AM ET 2010-09-21T12:16:20

PALM CITY, Fla., Sept. 21, 2010 (GLOBE NEWSWIRE) -- Information Systems Associates, Inc. (OTCBB:IOSA), a data center optimization software, services and solutions company, today announces that it has secured a contract to perform services for a major regional bank with $140 billion in assets.  This project will launch by the end of September and will be completed in the fourth quarter.  These contracts are in addition to recently announced projects including a global conglomerate Fortune 100 company, Fortune 500 Communications company, Fortune 100 wireless carrier, a Fortune 100 retailer and a Fortune 1000 bank.

Joe Coschera, the President and Chief Executive Officer of Information Systems Associates, stated, "This announcement represents another important milestone for our Company.  As our recent history has shown, we are rapidly building our deal pipeline, which is direct evidence of the uniqueness and power of our new and patented OSPI v.2 data center solution.  We expect to make similar exciting announcements during the remaining period in 2010 and 2011 as we continue to aggressively build our deal pipeline."

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About Information Systems Associates

Information Systems Associates, Inc. (OTCBB:IOSA) based in Palm City, FL. is a leading provider of turnkey  data center management solutions  with a suite of services including ; data center inventory management data center management software  and  data center optimization.  Its core service utilizes its proprietary technology "OSPI software" (On Site Physical Inventory(R)) which provides a tool set allowing customers to create a highly accurate data set of their current IT inventory and assets.  This accurate information is then imported into software that enables businesses to make meaningful decisions on Data Center Management that leads to optimization of resources, cost reductions and significant ROI.

For more information visit our website  http://www.isa-inc.net

Safe Harbor

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 (the "Act"). Additionally, words such as "seek," "intend," "believe," "plan," "estimate," "expect," "anticipate" "project" and other similar expressions are forward-looking statements within the meaning of the Act.  Some or all of the events or results anticipated by these forward- looking statements may not occur.  Factors that could cause or contribute to such differences include the ability of Information System Associates to attract customers for its services, and continue developing innovative datacenter optimization solutions.  Further information on Information Systems Associates' risk factors is contained in its filings with the Securities and Exchange Commission, including the Form 10-KSB for the year ended December 31, 2009 and the Form 10-QSB filed June 30, 2010.  Information Systems Associates does not undertake any duty nor does it intend to update the results of these forward-looking statements.

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