Video: Study: More coffee equals less risk of prostate cancer

  1. Transcript of: Study: More coffee equals less risk of prostate cancer

    BRIAN WILLIAMS, anchor: We turn to health news tonight. You know the rule of thumb on all those medical studies that come out? If you don't like the findings, wait for the next one, it's sure to have the opposite finding. Well, tonight there's news about coffee . And if you're a coffee drinker, we think this is a study you'll like. It's a big one, it comes from the Harvard School of Public Health , and it seems to hold strong evidence that coffee can help prevent prostate cancer . Our report from our chief science correspondent Robert Bazell .

    Unidentified Man #1: Hey, how are you doing today?

    ROBERT BAZELL reporting: At Sip the Experience coffee shop in Atlanta and around the country today, men were glad to hear about the new findings.

    Unidentified Man #2: Before I thought it was really bad for your health, you know, to drink a lot of coffee . So that's good news.

    Unidentified Man #3: It gives me even more of an incentive to drink coffee , that's for sure.

    BAZELL: Researchers at the Harvard School of Public Health studied almost 48,000 men for 12 years and found that drinking up to six cups of coffee a day lowered the risk of prostate cancer .

    Dr. LORELEI MUCCI (Harvard School of Public Health): The strongest association was actually for prevention of advanced stage or lethal prostate cancer , and there we found that the men who drank the most coffee had a 60 percent lower risk of developing lethal prostate cancer during follow-up.

    BAZELL: Surprisingly, the study found no difference between regular and decaffeinated coffee . If not caffeine, what is the cause? Previous research shows coffee beans contain antioxidants, anti-inflammatory compounds, and chemicals that help control blood sugar and hormone levels. But here's what's puzzling. Thirty years ago this same laboratory that studies epidemiology, the causes of disease, found that drinking coffee increased the risk for a different deadly cancer.

    Unidentified Reporter: A new medical study out today indicates that coffee drinking may be related to cancer of the pancreas .

    BAZELL: The Harvard researchers later said those results were wrong, but this time they say the study got it right.

    Dr. WALTER WILLETT (Harvard School of Public Health): Like almost all sciences over the last 30 years, epidemiology has become much better, much more powerful in its methods.

    BAZELL: The scientists say even this latest study needs to be repeated. But at the very least, men can go ahead and enjoy a daily cup or more of coffee . Robert Bazell , NBC News, New York.

By Robert Bazell Chief science and health correspondent
NBC News
updated 5/17/2011 7:21:22 PM ET 2011-05-17T23:21:22

Coffee is good for men, according to research released Tuesday from the Harvard School of Public Health. Those who who drank the most coffee — regular or decaffeinated — have the least risk for prostate cancer, especially the deadliest forms of the disease, the 12-year study of almost 48,000 male health professionals found.

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But, wait! Almost exactly 30 years ago this same lab in a separate study concluded that in men and women coffee increased the risk of pancreatic cancer, which is almost always deadly.  That study got widespread publicity, but not long afterward the researchers said: "Oops, we made a mistake." Coffee, they said, has no effect on the risk of pancreatic cancer.

That flip-flop from such a prestigious institution contributed greatly to the public distrust of the science of epidemiology and the widespread perception that “one day they say something is good for us and the next day they say it is bad.”

Today's news seems pretty clear. Men who drank the most coffee, six cups or more daily, had a 60 percent lower risk of developing lethal prostate cancer — and 20 percent lower risk of developing any form of the disease, according to the study published in the online edition of the Journal of the National Cancer Institute.

Even lighter consumption — up to three cups daily — was associated with a 30 percent lower risk of lethal prostate cancer.

Because the results were the same whether the coffee was regular or decaffeinated, it's not the jolt of the java that provided the protection, researchers said. Instead, the benefit is likely linked to other compounds in coffee that act as antioxidants, reduce inflammation and regulate insulin.

The new research studied nearly 50,000 U.S. men who reported their coffee consumption every four years from 1986 to 2008. It backs up previous studies that found coffee consumption was associated with lower risk of a wide range of diseases including Parkinson's, type 2 diabetes and liver cancer.

Taken together, they support the notion that a wicked coffee habit actually may be good for your health.

Complex and changing
So, what happened in the last three decades? For one thing, the science of epidemiology — the study of health-related events or disease, including public health research — has matured a lot since then and researchers have learned not to make too much of findings that may be later disproved.

It is never easy to study human beings who live in a complex, ever-changing environment. Humans are not lab rats where everything can be controlled. Still, even with the limitations, some kinds of epidemiological studies provide far better evidence than others.

According to Dr. Meir Stampfer, now the chief of epidemiology at Harvard School of Public Health and a co-author of today’s coffee paper "the main difference between (the new study) and the discredited pancreas finding is that ours is prospective, so there is no issue with recall bias."

What does that mean? The first pancreas cancer trial was what is called a “case control trial.” The scientists questioned  369 patients with pancreatic cancer and asked them about their dietary and other habits. Then they asked 644 healthy people the same question. The use of coffee jumped out so much that the authors came to the frightening conclusion that coffee use might account for a substantial proportion of the cases of this disease in the United States.

It sounds scary, but “recall bias” can affect the outcome of a study. People with a terrible disease like pancreatic cancer often wonder why they got it, even though there can be no answer. If they learn that the scientists are interested in coffee as a possibility, they are far more to remember every cup they ever drank than the normal controls. That's where the bias occurs.

The current research is called a prospective trial, which follows participants over a period of time. For the course of the trial, the volunteers have been filling out forms about their dietary and other habits, including tracking their coffee consumption. So when scientists look at the new results, they can be far more confident.

Of course there's interest in the connection. Prostate cancer is the most frequently diagnosed form of cancer and the second leading cause of cancer death among U.S. men, affecting one in six men during their lifetime. More than 2 million men in the U.S. and 16 million men worldwide are prostate cancer survivors.

Some skepticism may remain, but at the very least the new coffee study shows that men who enjoy their java have nothing to fear and may get some cancer-fighting benefit.

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