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updated 12/29/2012 7:31:58 AM ET 2012-12-29T12:31:58

KARACHI, Pakistan (Reuters) - A bomb went off on a bus in the southern Pakistani city of Karachi on Saturday killing six people and wounding 48, police and a hospital official said.

Pakistan's commercial capital and biggest city has seen numerous militant attacks over the past 10 years and is also plagued by violence between rival ethnic-based factions.

The bus sustained serious damage in the explosion and a subsequent fire. While police said the bomb had been planted on the bus, provincial official Sharfud Din Memon said it was left on a motor-bike and went off as the bus passed.

Eight of the wounded were in critical condition, said Seemi Jamali, a doctor at Jinnah Hospital.

(Writing By Katharine Houreld; Editing by Robert Birsel)

(c) Copyright Thomson Reuters 2012. Check for restrictions at: http://about.reuters.com/fulllegal.asp

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