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Mice Given Human Brain Gene Show Boosted Intellect

Although it's far from the sort of brain transplant beloved by science fiction enthusiasts, scientists have taken one step in that direction: they have spliced a key human brain gene into mice. Scientists used hundreds of mice genetically engineered to carry the human version of Foxp2, a gene linked to speech and language. In a 2009 study, mice carrying human Foxp2 developed more-complex neurons and more-efficient brain circuits. Building on that, neuroscientists at the Massachusetts Institute of Technology trained mice to find chocolate in a maze. Mice with the human gene learned the route as well by seven days as regular mice did by 11, scientists reported in Proceedings of the National Academy of Sciences. However, when the scientists removed all the landmarks in the room, so mice could only learn by the feel-of-the-floor rule, the regular rodents did as well as the humanized ones. They also did just as well when the landmarks were present but the floor textiles were removed. It was only when mice could use both learning techniques that those with the human brain gene excelled.

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IN-DEPTH

--- Reuters