Lindsey will have to wait a year of watching and healing before she can try. She and other women hoping to have the procedure had first to undergo in vitro fertilization (IVF) treatment to produce six to 10 healthy embryos, which can be implanted if the transplant is a success.
The hospital screened more than 250 women to identify 10 who qualified for the clinical trial. They needed healthy ovaries to produce the egg cells used for the IVF.
After she has one or two children, Lindsey will have to undergo surgery again to remove the uterus. Doctors don't consider it's worth the risk to her health to continue taking anti-rejection drugs for life.
Surgeons in Sweden performed the first publicized uterus transplants and say five healthy babies have resulted from nine transplants so far.
The Cleveland Clinic team was not able to say how much the surgery cost or would cost in the future, or whether health insurers would pay for it.
It's also not clear just how many people might benefit from such a transplant. It could conceivably help transgender women bear children as well as women born without a functioning uterus or those who have lost a uterus to disease.
The American Society for Reproductive Medicine, the Organ Procurement and Transplantation Network, the American Society of Transplantation, the American Organ Procurement Organization and other groups are planning a meeting to draw up guidelines for centers planning to offer uterus transplants.
One big question will be who should be eligible to get them.