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Heroin addicts clamor for hard-to-get medicine

/ Source: The Associated Press

Krystal began using heroin when she was 14, and soon hit bottom. But at 18, she says she is drug-free, holds down a job, attends beauty school and cares for her toddler son. She credits a relatively new medication called buprenorphine with freeing her from heroin’s grip.

“Amazing,” “incredible” and “lifesaving” are a few of the words addicts use to describe buprenorphine, a pill that blocks heroin cravings.

The problem, some say, is that Congress has made it hard to get the drug, and health professionals are pressuring the government to expand access.

Available in this country since 2002, buprenorphine is an alternative to methadone, which has been used to treat heroin addiction since the 1960s. Buprenorphine is also used to treat addictions to prescription painkillers like OxyContin, Percocet and Vicodin.

“It has been extraordinarily effective in the patients we have given it to,” said psychiatrist Dr. Herbert Kleber of Columbia University.

Lasts longer than methadone

Doctors say buprenorphine is longer-acting than methadone, more difficult to overdose on and easier to withdraw from. Addicts say “bupe” gives them a feeling of clearheadedness they do not get with methadone. Also, they can be treated in the privacy of a doctor’s office; methadone, under federal law, is available only at public clinics.

Krystal’s doctor, J. Charles Lentini, said he has a waiting list of 185 addicts — many of whom are continuing to abuse drugs while they wait.

Even more problematic is the restriction on large medical practices. For example, Kaiser Permanente, the nation’s largest not-for-profit health maintenance organization with 8.2 million members, operates eight medical groups around the country, meaning it can treat only 240 patients at any one time nationwide.

Legislation would eliminate restriction

Bills pending in Congress would eliminate the 30-patient restriction for group medical practices while retaining it for individual doctors. The Senate passed similar legislation last year, but it died in the House.

“It clearly was not our intention” that addicts have less access to buprenorphine because they go to a group practice, said Sen. Carl Levin, D-Mich., co-author of the 2000 law that paved the way for doctors to prescribe buprenorphine but also established the 30-patient limit. Levin introduced the bill now pending.

Meanwhile, the U.S. Substance Abuse and Mental Health Services Administration is working on a regulatory fix to expand access to buprenorphine. “The group practice issue we see very much as a critical barrier,” said Robert Lubran, the agency’s director of pharmacologic therapies.

Krystal said she spent eight agonizing months on Lentini’s waiting list before finally getting her buprenorphine prescription last month. She entered detox two or three times while she waited, and returned to heroin each time she was discharged.

'It was torture'

“It was torture,” she said. “I just wanted to feel normal again.”

Another of Lentini’s patients, David, used heroin for six years and has been on buprenorphine for 13 months. The 43-year-old day trader, who spent time in prison for accidentally killing a woman with his car while high, said he thanks God that he got the drug when he did.

“If there was a waiting list, I’d be in jail now, because my urine would be hot,” he said.

Both Krystal and David spoke on condition that their last names not be used.

The Office of National Drug Control Policy estimates there are 800,000 heroin addicts in the United States, and about 20 percent of them receive methadone.

The 30-patient limit on buprenorphine is not the only barrier. Fewer than 1 percent of the nation’s doctors — 4,850 out of 600,000 — have received Drug Enforcement Administration certification to prescribe buprenorphine, which is manufactured by Reckitt Benckiser and sold under the brand names Suboxone and Subutex.

Kleber said the manufacturer told him last year that only 1,500 doctors had written a buprenorphine prescription. Reckitt Benckiser officials did not return a call.

Many doctors shy away from treating heroin addicts because they believe those patients will be disruptive, Kleber and others said. Also, buprenorphine is expensive, at around $300 to $350 a month, and is not always covered by insurance.