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Nobel Prize for Chemistry Goes to Inventors of Imaging Technique

Researchers who developed cryo-electron microscopy, a technique that lets us image viruses and tiny cell structures, won the Nobel Prize in Chemistry.
A cryo-electron microscopy image of the Zika virus structure.
A cryo-electron microscopy image of the Zika virus structure. Richard Kuhn, Purdue University / Purdue University

You know those images of the Zika virus that make it look more like a piece of art than a killer microbe? The shot that captures a Salmonella bacterium injecting explosive materials into a cell to literally blow it apart? Those curly ribbon-like structures that turn out to be structures inside a cell that help us hear?

You can thank the three winners of the Nobel Prize in Chemistry for those fascinating images.

A cryo-electron microscopy image of the Zika virus structure. The triangle highlights the asymmetric unit of the virus.Richard Kuhn, Purdue University / Purdue University

“The Nobel Prize in Chemistry 2017 is awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for the development of cryo-electron microscopy, which both simplifies and improves the imaging of biomolecules,” the Nobel Committee said in announcing the prize Wednesday.

The American, Swiss and British researchers independently solved big problems in capturing pictures of very, very small things.

The images are good for more than just illustrating news stories about killer viruses.

The Nobel Prize in Chemistry was award for developing cryo-electro microscopy.Johan Jarnestad / The Royal Swedish Academy of Sciences

Other researchers can use these kinds of images to design drugs that precisely fit into the structures, like a lock and key, to stop infection or to improve a cell’s function.

Related: Gravitational Wave Work Wins Physics Nobel

Other teams had designed x-ray crystallography to image tiny structures, but the process did not work with many living structures.

The three winners figured out how to freeze, preserve and then see live structures, while not getting such tiny things mixed up with the background.

Members of the Nobel Committee: Sara Snogerup Linse, the Secretary General of the Royal Swedish Academy of Sciences; Goran Hansson and Peter Brezezinski sit in front of a giant screen displaying the winners of the 2017 Nobel Prize in Chemistry : Jacques Dubochet from Switzerland, Joachim Frank from the US and Richard Henderson from BritainJonathan Nackstrand / AFP - Getty Images

“By solving more and more structures at the atomic level we can answer biological questions, such as how drugs get into cells, that were simply unanswerable a few years ago,” said Jim Smith, director of science at Britain’s Wellcome Trust.

“Now we are there – the sky is the limit,” the Nobel Committee said in its announcement.

“Jacques Dubochet, Joachim Frank and Richard Henderson have, through their research, brought ‘the greatest benefit to (humankind).’ Each corner of the cell can be captured in atomic detail and biochemistry is all set for an exciting future.”

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Dubochet, who is Swiss, is an honorary professor of biophysics at the University of Lausanne. He figured out how to cool water so rapidly it turned into a glass, thus allowing an electron microscope’s beams to diffuse evenly and make a clear image.

Frank's image analysis for 3D structures.Johan Jarnestad / The Royal Swedish Academy of Sciences

Frank was born in Germany but is now a professor of biochemistry and molecular biophysics at Columbia University in New York. Then at the New York health department, he figured out how to make a computer discriminate between the pieces target images, whether a virus or a protein, and whatever was in the background.

This is a three-dimensional image of enterovirus D68 (center) reconstructed from cryo-electron micrographs (background).Yue Liu and Michael Rossmann / Purdue University

Scots-born Henderson is a program leader at the Medical Research Council’s Laboratory of Molecular Biology at Britain’s University of Cambridge. He ran test after test using different electron microscopes to make it all work.

Related: Amazing Images May Help Scientists Design Drugs

Earlier this week the Nobel Committee awarded the Medicine prize to three Americans for their work on circadian rhythms – the body clock inside cells – and the Physics prize to U.S. researchers for building giant detectors that measures gravitational waves from the collision of two black holes.

The committee also awards prizes in Economics, Literature and the Nobel Peace Prize.