The Seattle Biomedical Research Institute will pay volunteers as much as $4,000 to be bitten by mosquitoes infected with malaria.
Scientists say no lives are in danger because the volunteers can be cured. The institute is testing which vaccines work fastest.
The head of the program, Dr. Patrick Duffy, said volunteers will spend several nights under medical supervision in a hotel.
All of the human trials will be reviewed for safety by the Food and Drug Administration.