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A 21-month-old Michigan girl died of Enterovirus D68, officials said, becoming the second child whose death was directly blamed on the virus that has caused severe respiratory illness across the country.

Madeline Reid died Friday afternoon from Enterovirus D68, according to Children's Hospital of Michigan in Detroit. Its chief medical officer, Dr. Rudolph Valentini, said in a statement that the Centers for Disease Control and Prevention confirmed the illness after the Clinton Township girl's arrival, but did not specify which day she arrived.

"It is never easy to lose a child, and our entire health care team at the Children's Hospital of Michigan is deeply saddened by this family's loss and mourns with them during this very difficult time," Valentini said.

A New Jersey state medical examiner said last week that a 4-year-old boy died of the virus, and the CDC says five people infected with the virus have died, but it's not clear what role the virus played. The CDC said in a release this week that the virus has sickened 691 people in 46 states and Washington, D.C.

Enterovirus D68 can cause flu-like symptoms and respiratory problems. The virus can be spread through coughing, sneezing and contact with contaminated surfaces. There is no vaccine or specific treatment.

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— The Associated Press