A 150-mile section of Interstate 80 reopened around midday Monday after being closed Sunday due to a multi-vehicle accident that killed six people.
At least 20 vehicles crashed in blizzard conditions Sunday about 90 miles west of Cheyenne.
The accident scene had been cleared up by Monday morning but the interstate remained closed for several hours "just to make sure we don't have a repeat," a highway patrol dispatcher said.
An undetermined number of injured victims were taken to hospitals in Laramie and Rawlins, the patrol said.
Several injured were admitted to Carbon County Memorial Hospital in Rawlins. Their conditions and the nature of their injuries were not immediately available.
Troopers at the scene reported zero visibility due to strong winds and blowing snow Sunday.
The crash, which involved semitrailers and passenger vehicles, was reported west of Laramie shortly after 4 p.m. Several smaller crashes also occurred behind the 20-vehicle crash, troopers said.
The interstate was closed between Rawlins and Cheyenne. A 50-mile stretch of the highway between Cheyenne and Laramie was dry but was closed at the request of Laramie officials, who said there was no parking left in the town for semitrailers. University of Wyoming and local Laramie residents were allowed to travel between Laramie and Cheyenne.
The highway patrol also closed U.S. 30 in the Laramie area — which often serves as a detour for I-80 — because of the weather and reports of crashes.