The storm that earlier swamped the Pacific Northwest had moved over the Midwest by Wednesday, causing airport problems and at least two deaths, and dumping several inches of snow in parts.
The snow created delays at several Midwestern airports by Tuesday evening and caused a bus crash in Indiana that injured 17 people, authorities said.
A small airplane headed to Buffalo, N.Y., crashed amid falling snow near the airport in Columbus, Ohio, killing two on board, authorities said. Weather was being considered by investigators trying to determine a cause of the crash.
NBC affiliate WMAQ-TV reported more than 100 flight cancellations at O'Hare International Airport as of late Tuesday evening. Wednesday morning, more than 50 American Airlines flights alone were showing as canceled.
At Midway International Airport, flights were delayed up to 60 minutes Tuesday evening.
A snow advisory was issued for the Chicago area extending through Wednesday afternoon. The area saw 4 inches of snow Tuesday, and one more inch was predicted Wednesday.
Minor vehicle accidents were reported overnight.
"All night long we've been having spinouts and people bouncing off walls," WMAQ-TV reported state Trooper Mark Hall as saying.
Milwaukee's airport was shut down for several hours Wednesday but had reopened by midday.
As much of 9 inches of snow was reported in parts of North Dakota.
Western Ohio was predicted to get as much as 7 inches before the storm moved out Wednesday.
A woman was killed Tuesday night after she lost control of her car in a snowstorm, crossed a highway’s center line and crashed with another car head-on about 40 miles southeast of Madison, Wis. The driver of the other car was unhurt.
A second fatality was reported in Wisconsin as well.
Snow advisories extend from northeast Illinois to southern Ohio and east to the Delaware and southern New Jersey coasts. Some 1-3 inches of snow is predicted for parts of that area, while the central Appalachians could get 6 inches.
The Washington, D.C., area was also seeing snow — the first of the season for the nation's capital.
Parts of the area could receive 1-3 inches by Wednesday night, NBC affiliate WRC-TV reported.