Investigators have removed four bags of evidence from the home where a missing Orlando 2-year-old lived.
Orange County sheriff's Sgt. John Allen says investigators also had a "nice talk" with Caylee Anthony's grandparents during Wednesday's 2 1/2-hour search of the couple's home.
It was the fourth time they have been at the home where Caylee lived with her mom and grandparents.
Her 22-year-old mother, Casey Anthony, remains jailed on $500,000 bond. She was charged Tuesday with child neglect and filing a false statement.
Investigators say she lied to them and didn't report her daughter missing for more than a month.
Casey Anthony's attorney has denied the charges and says the mother believes Caylee is still alive.