It's an all-male, all-veteran crew for space shuttle Atlantis' final flight.
Six astronauts are aboard for this third-to-last shuttle mission. NASA is retiring its three remaining shuttles so it can focus on getting astronauts back into true outer space.
Atlantis' astronauts are putting off any commemorations and, for now at least, focusing on the work awaiting them at the International Space Station.
"This is probably the kind of thing that's really going to hit all of us after we're done with the mission and we realize what part of history we may have played," said commander Kenneth Ham.
A brief look at each:
Commander Ken Ham
Born Dec. 12, 1964, in Plainfield, N.J.
Nickname: Hock (as in "ham hock").
Ham uses "the avoidance technique" when it comes to dealing with the dangers of spaceflight.
"I've convinced myself that my old job of flying jets in the Navy was far more dangerous than this one, and if I managed to live through all of that, this is a piece of cake," he said. "I really don't think about it."
Ham, 45, is a Navy captain who flew missions over Iraq and Bosnia. He served as an air wing strike leader as well as a night vision goggle instructor. Picked as an astronaut in 1998, Ham flew to the space station as a co-pilot in 2008. This is his first time heading a mission.
Wife Michelle is an instructor for space station astronauts, teaching them how to live and work up there. The Hams have two sons, ages 16 and 17. Ken Ham plans to leave NASA after this flight and return full time to the Navy.
Pilot Dominic Antonelli
Born Aug. 23, 1967, in Detroit.
Nickname: Tony (as in "Antonelli").
Antonelli is making his second spaceflight in just over a year. "This is how it should be for everybody," he said. "We should be flying these things every couple of weeks and giving as many people a chance to do it as we can."
It's sad that so few missions are left, he said. "The space shuttle's such a great machine. But I think we really need to leave low-Earth orbit at some point and that's our one limitation. So moving on to something new, whatever that is, that's going to be pretty exciting."
Antonelli, 42, a Navy commander who grew up in Indiana and North Carolina, became an astronaut in 2000. He and his wife Janeen have two sons, ages 6 and 9.
Flying back-to-back missions means Antonelli hasn't gone snowboarding — a passion right up there with flying — for more than two years. It's one of the high-risk activities that are banned for astronauts who are within a year of launching. He figures he'll get back on the slopes this winter.
Robotics lead Piers Sellers
Born April 11, 1955, in Crowsborough, England.
From his home in England, Sellers followed NASA's moon landings in the late 1960s and was "completely captivated" when he saw the movie "2001: A Space Odyssey" at age 13.
"It made a huge impression on me and it stayed with me," he said. "And the real thing has not disappointed."
"Of course, we all wish we were further along," he added. "But I think we're going to get there. I think that during our lifetime, we're going to see people on Mars."
Sellers, 55, a biometeorologist, grew up in Sussex. He moved to the United States to work and, in 1991, became a U.S. citizen. NASA chose him as an astronaut five years later.
On his first two trips to the space station, Sellers racked up six spacewalks. This time, he'll stay indoors and operate the big robot arm. He's taking up a small piece of the tree from which an apple fell nearly 350 years ago in England and inspired Sir Isaac Newton to formulate his theory on gravity.
Sellers and his wife, Mandy, a nurse, have a daughter and son, both in their 20s.
Spacewalker Garrett Reisman
Born Feb. 10, 1968, in Morristown, N.J.
Nickname: Big G.
Reisman, one of the astronaut corps' shorter astronauts at 5-foot-4½, is jokingly called "Big G" by his crewmates.
He can't wait to grow temporarily in weightlessness, as all astronauts do thanks to elongated spines. He stretched to 5-foot-6 during his three-month stay at the space station in 2008. Going back for a short visit is reward for the four years of training he put in last time. He'll perform two spacewalks.
Reisman, 42, became an astronaut in 1998 after working as an engineer on spacecraft navigation for what was then TRW Inc.
He's taking up the original federal document proclaiming May as Jewish American Heritage Month. "As a Jewish kid growing up in New Jersey, the concept of being an astronaut was really something I didn't think was possible," he said. As he watched films of the Apollo moonshots, "it was all a bunch of white men, non-Jewish people flying, test pilots."
Now, his message to all Americans is, "this is something that's within their realm of possibility."
"There's nothing more powerful than making a child believe there's nothing they can't do, and that's turned out to be true for me."
Wife Simone Francis is an oceanographer. Home is Parsippany, N.J.
Spacewalker Mike Good
Born Oct. 13, 1962, in Parma, Ohio.
Nickname: Bueno (as in Spanish for "good").
Good's only other spaceflight was to the Hubble Space Telescope last May. "I thought Hubble was big, so I can't imagine what the station's going to look like as we rendezvous with it," he said.
Working on Hubble in the shuttle's payload bay "was like going out and working in your garage," he said. This time, he'll "get to wander around the neighborhood," venturing out to the fringes of the space station on two spacewalks to replace batteries.
Good, 47, specialized in weapons systems for the Air Force. He became an astronaut in 2000 and retired from the military as a colonel last year.
With the shuttle program winding down, long station missions will be "the only game in town" so he plans to check out the place and see if it's somewhere he'd like to live in the future.
He and wife Joan, an emergency room nurse, have two sons in their 20s and a 12-year-old daughter, as well as a 1-year-old grandson. He's from Broadview Heights, Ohio.
Spacewalker Stephen Bowen
Born Feb. 13, 1964 in Cohasset, Mass.
Bowen took a lot of kidding from his tile-laying, house-painting brothers when he spent his first shuttle mission working with caulk guns.
This time, he'll change out batteries and do other chores during a pair of spacewalks. "It's not changing double-A batteries. It's a little more complicated than that. But they still give me a hard time," Bowen said.
Bowen, 46, a Navy captain, spent the 1990s in submarines. In 2000, he became the first submarine officer selected as an astronaut. Like working underwater, spaceflight is "an understood risk," he said.
"These are the choices I've made. I don't think anybody has a big question about that. I'm sure it stresses my mother out."
Bowen and wife Deborah, a former schoolteacher, have three teenage children.
As for this being Atlantis' last flight, "It's kind of hard to be wistful when you're spending your whole life trying not to be overwhelmed by the history of what you're doing."
This report includes information from The Associated Press and msnbc.com.