CORRECTING and REPLACING -- Nanosphere to Release Q1 2011 Results and Hold Investor Call Wednesday, April 27

/ Source: GlobeNewswire

NORTHBROOK, Ill., April 21, 2011 (GLOBE NEWSWIRE) -- In a release issued earlier today under the same headline by Nanosphere, Inc. (Nasdaq:NSPH), the time of Nanosphere's first quarter 2011 earnings announcement was incorrect. Nanosphere will report its results for the first quarter 2011 before the market opens on Wednesday, April 27, 2011, not after the market closes. The corrected release follows:

Nanosphere, Inc. (Nasdaq:NSPH), which develops, manufactures, and markets advanced molecular diagnostics systems, will report its results for the first quarter 2011 before the market opens on Wednesday, April 27, 2011. The company will also hold a live investor conference call and webcast at 10:30 A.M., Eastern Time.

The teleconference can be accessed by dialing 888.679.8040 (U.S./Canada) or 617.213.4851 (international), participant code 60282367. The call will also be broadcast live over the Internet and can be accessed by interested parties at the Investor Relations tab on the Nanosphere website: www.nanosphere.us.

Participants may pre-register for the call at:  Pre-registrants will be issued a pin number to use when dialing into the live call, which will provide quick access to the conference by bypassing the operator upon connection. For interested individuals unable to join the call or webcast, a replay will be available through May 4, 2011 by dialing 888-286-8010 or for international calls 617-801-6888, pass code 93038205, or on the company's website.

About Nanosphere, Inc.

Nanosphere develops, manufactures, and markets an advanced molecular diagnostics platform, the Verigene® System, for direct genomic and ultra-sensitive protein detection. This easy to use and cost effective platform enables simple, low cost and highly sensitive genomic and protein testing on a single platform. Nanosphere is based in Northbrook, IL. Additional information is available at .

The Nanosphere, Inc. logo is available at .

CONTACT: Investors: Nanosphere, Inc. Roger Moody, 847-400-9021 Chief Financial Officer rmoody@nanosphere.us Media: The Torrenzano Group Ed Orgon, 212-681-1700 ed@torrenzano.com