A collision involving a tour bus and two other vehicles on a busy expressway near downtown Chicago sent 20 people to the hospital, officials said.
Paramedics took 20 people to local hospitals following the crash on the northbound Dan Ryan Expressway, Chicago Fire Department spokesman Kevin MacGregor said.
An additional 31 people on the bus refused treatment, he added. Eight people were in good condition and 12 were in fair condition.
Northbound lanes of the expressway on the city's South Side were temporarily closed.
Days before the Virginia accident, the Department of Transportation announced that a crackdown on passenger buses conducted in the first two weeks of May put 127 drivers and 315 vehicles out-of-service after over 3,000 unannounced inspections.
A bus crash in New York City in March also left 15 people dead.