Mr. 305 had a message for presidential hopefuls at the Premios Juventud on Thursday night.
"Im not a politician, I'm a musician, but most of all, I'm Latino," said Pitbull in Spanish to cheers from the crowd.
So he then said to Marco Rubio, Jeb Bush and Hillary Clinton, "Ponte en las pilas porque Donald Trump no puede ser presidente," which loosely translates to "get it together, because Donald Trump cannot be president."
Then he had a message for The Donald.
"Ten cuidado con El Chapo, Papo!" which brought the house down. (Papo is used like the word "buddy.)