For the major cities along the I-95 corridor, forecasters said Washington could get 4 to 6 inches of snow, Baltimore 6 to 8 inches, Philadelphia 8 to 12 inches, New York 5 to 9 inches, and Boston 4 to 8 inches.
The spring storm comes as an area from Wilmington, North Carolina, to Florida braced for heavy thunderstorms, damaging winds and possible tornadoes.
Energy from the Southeast storm is "going to be used to crank up our next nor'easter," Weather Channel meteorologist Jim Cantore tweeted.
The pending nor'easter is also likely to be accompanied by sustained winds of 15 to 25 mph and gusts of 30 to 60 mph in some coastal areas, making for a blustery and chilly Wednesday, the National Weather Service said.
This system follows in the footsteps of a trio of deadly nor'easters that bashed the East Coast earlier this month.
The first nor'easter of the month struck on March 2 and halted flights and caused chaos for commuters. A second nor'easter on March 7 left thousands without power and left up to 2 feet of snow on the ground. The most recent nor'easter on March 12 hammered parts of the Northeast and New England.