A storm is forecast to drop a foot of snow on the Midwest and Great Lakes starting Monday before doing the same in the Northeast over the next two days.
The stretch between eastern Iowa and northern Michigan could get up to a foot of snow by Tuesday before the storm moves to New York and New England, parts of which could also get a foot of snow or more by Wednesday, according to the National Weather Service.
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The NWS warned of "significant travel impacts" and "power disruptions" in those parts of the country during the beginning of the week.
In the warmer South, the same storm system will bring rain from Louisiana to the Ohio Valley, and could "move over the same areas repeatedly" causing flash flooding, according to the NWS.
On the opposite side of the country, the Northwest was grappling with uncharacteristic cold and heavy snowfall from Washington down to Northern California, which woke up to 1 to 4 inches on the ground Monday morning.
Seattle has gotten more snow this February than ever before, at 14.1 inches, according to the NWS, and more snow and freezing rain was expected to fall there through Wednesday.
Classes were canceled at University of Washington's campuses and Seattle Public Schools were also closed Monday.
One person has died as a result of the nasty Northwest weather. A woman lost control of her SUV on ice covered roads near Florence, Oregon, and slammed into a delivery truck, leaving the woman and her dog dead, according to Oregon State Police.