There were conflicting accounts as to which side of the porous border the strikes had hit, but an Afghan villager described to NBC News how he watched as four unmanned aircraft hovered over three compounds before launching missiles at them.
"The drones fired six missiles and pounded three different sanctuaries of the Afghan Taliban,” Mohammad Yaqoob, a resident of the Nazian district of Nangarhar province told NBC News by telephone. "The bodies of most of those killed ... were burnt and beyond recognition.”
A senior member of the Afghan Taliban told NBC News that 10 of their members had been slain, but claimed they were low-level militants.
The U.S. military officials in Afghanistan would not comment on the news.
U.S. drone strikes have prompted protests and raised tensions both in Pakistan and in Afghanistan. There has been a 139-day lull in the hits in Pakistan, which has allowed the government room to negotiate with the Pakistani Taliban. These talks did not bear fruit.
Meanwhile, an unnamed Afghan security source denied there had been a drone strike Afghanistan. The presidential palace did not respond the requests for confirmation or comment.
Taliban commander Qari Ziaur Rahman in Afghanistan’s Kunar province told NBC News that he too had heard about the strike and his comrades’ deaths.
He went on to explain that a large number of militants had taken refuge in Pakistan during the recent pause in strikes.
“The drones would fly over us but never fired missiles due to recent agreement between Pakistan and United States not to carry out missile strikes during peace talks by the government with the Pakistani Taliban," he said.
"We developed some differences with the Pakistan-based militant group of Lashkar-e-Islam and then we moved to Nazian area of Nangarhar near Jalalabad," he added.
Fazul Rahim in Kabul contributed to this report.