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One Israeli was killed and three others injured in two separate stabbing attacks on Monday, according to officials.
The violence came ahead of Secretary of State John Kerry's visit to the region this week amid a months-long spiral of bloodshed.
Police spokesman Micky Rosenfeld said two females armed with scissors were behind the first attack of the day, in central Jerusalem. Both were shot at the scene; one was killed.
The Israeli Defense Forces said on Twitter that an 80-year-old and a 27-year-old were injured and evacuated for emergency treatment following the attack in central Jerusalem.
However, police later told NBC News that the elderly casualty was actually a Palestinian male aged around 70 who is from the West Bank.
Police said both attackers were in their teens; information on their conditions was not immediately available.
The Israeli military said that a few hours later a Palestinian stabbed one Israeli to death and wounded another at a gas station near Modiin. The attacker was shot dead by responding security forces, the military said.
Another attempted stabbing attack was thwarted at the Samaria junction, the military added. It said a Palestinian drew a knife, approached security forces and attempted to stab a soldier before being shot dead.
Monday's attacks follow a particularly bloody weekend in the recent spate of violence in Israel and the West Bank.
A 20-year-old Israeli woman was stabbed to death by a Palestinian on Sunday in one of at least three separate incidents which saw three attackers shot dead. Over the past two months, Palestinian stabbings and other attacks have killed nearly 20 Israelis, while 87 Palestinians have been killed by Israeli fire, according to The Associated Press.