She has also withstood attacks by controversial, right-wing commentator and Donald Trump fan Katie Hopkins.
Right-leaning U.K. newspaper The Sun branded this issue of Vogue, "Meg's Lefty Issue."
For Meghan, who asked Enninful if she could edit the issue, it was a rare opportunity. She is the first co-editor of the September issue in the magazine's history.
“Over a steaming cup of mint tea, we teased through how one can shine light in a world filled with seemingly daily darkness. Lofty? Of course. Worth it? Without question,” she wrote about her first meeting with Enninful in her guest-editor’s letter, released Monday evening.
Enninful wrote in his letter that aside from her advocacy for social change, Meghan’s very presence in the royal family is inspiring.
“I can’t overstate how much it meant to me to see HRH The Duke of Sussex marry this brilliant, biracial, American powerhouse. I simply never imagined that, in my lifetime, someone of my color would — or could — enter the highest echelons of our Royal Family,” he wrote.
"She bears all the hallmarks of a true activist," he added.
He isn’t the only one who has been impressed with her activism.
“She’s shown a real interest in the issues our women face, not just a surface level interest, but she’s trying to understand the issues to understand what needs to be done in order to make different futures for women,” said Alice Williams, the founder of Luminary Bakery, a social enterprise that Meghan called out in her guest-editor’s letter.
Luminary Bakery trains women in difficult circumstances to bake so they can break the cycle of poverty, violence and disadvantage.
Actor and body positivity advocate Jameela Jamil is one of the women featured on the cover.
“I remember being a teenage model when I was 15, starving myself thinking that that would bring me success or something like a cover of Vogue, and it's so amazing to find myself 20 years later, and 30 pounds heavier, actually being on the cover,” Jamil said in an interview with NBC News.
British Vogue hits newsstands and will be available to be digitally downloaded Aug. 2.