Actress Amber Heard filed for divorce from Johnny Depp, citing irreconcilable differences after 15 months of marriage.
She is seeking spousal support from the Oscar-nominated actor.
Heard listed their date of separation as Sunday in a filing in Los Angeles Superior Court. They have no children together.
Depp and Heard met while co-starring in the 2011 film "The Rum Diary." Depp's latest film, "Alice Through the Looking Glass," is due to be released on Friday.
The pair made global headlines last year when they ran into legal trouble for bringing their Yorkshire terriers, Pistol and Boo, into Australia as Depp was filming the latest "Pirates of the Caribbean" movie.
Heard was charged with two counts of illegally importing the pets and one count of producing a false document last July. A magistrate judge in April filed no conviction for Heard but issued a formal order to stay out of trouble for a month or face a $767 fine.
The breach in border security sparked what was gleefully dubbed the "war on terrier," and culminated in the pair recording a deadpan apology that was likened to a hostage video. Throughout the saga Depp engaged in a war of words with Australian Deputy Prime Minister Barnaby Joyce, who'd threatened to kill the dogs.
Earlier this week, Joyce boasted that he had gotten inside Depp's head like fictional serial killer Hannibal Lecter after the actor quipped that the ruddy-faced lawmaker appeared to be "inbred with a tomato" during an interview on "Jimmy Kimmel Live!"
Depp has one previous marriage and was in a long relationship with French actress and model Vanessa Paradis before he began dating Heard. Depp and Paradis are the parents of two teenage children.
The divorce was first reported Wednesday by celebrity website TMZ.