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As many as 50 cars are involved in a massive pileup on a central Pennsylvania highway, officials said Wednesday morning, as dangerous freezing rain continues to sweep eastward.

About 40 tractor-trailers and 10 cars were caught up in the wreck on Interstate 80 in Clearfield, local Fire Chief Chad Baughman told NBC affiliate WJAC.

A 13-mile stretch was closed on I-80, although the eastbound lanes were reopened around 10 a.m. ET. The scene is about two hours northwest of Harrisburg.

Clearfield Hospital was expecting at least three or four victims; the severity of injuries wasn’t immediately known.

The state Department of Transportation had earlier Wednesday closed a 10-mile stretch of I-80 in western Pennsylvania and a seven-mile stretch in Clinton County, which neighbors Clearfield County, after reports of jackknifed tractor-trailers.

This latest weather-related pileup follows another one last Friday outside of Philadelphia that involved as many as 100 cars and caused 30 injuries.

Damaged vehicles line the road after an accident on Interstate 80 in Clearfield Borough, Pa., on Feb. 19, 2014.WJAC
— Erik Ortiz