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Madonna flashes her new diamond-encrusted grills as she visits the Hard Candy Fitness center at Colosseo on Aug. 21, 2013 in Rome, Italy.
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Madonna poses in the press room during the 2013 Billboard Music Awards at the MGM Grand Garden Arena on May 19, 2013 in Las Vegas, Nevada where she accepted awards such as Top Touring Artist.
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Brahim Zaibat, Madonna and designer Riccardo Tisci attend the Costume Institute Gala for the "PUNK: Chaos to Couture" exhibition at the Metropolitan Museum of Art on May 6, 2013 in New York City.
Madonna visits school children in Chorwe, Malawi, on April 3, 2013. Madonna returned to the African nation, the home country of two of her adopted children and the place where her foundation, Raising Malawi, has built 10 schools.
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Madonna, second from left, sits with her children, from left, David Banda, Lourdes, Mercy James, and Rocco at Mkoko Primary School in Malawi on April 2, 2013.
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Anderson Cooper, left, and Madonna pose backstage at the 24th Annual GLAAD Media Awards on March 16, 2013, in New York. Madonna used the awards show podium to declare her opposition to the Boy Scouts of America's ban on gay scouts and scout leaders.
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Madonna performs during her "MDNA" tour at Atanasio Girardot stadium in Colombia on Nov. 28, 2012.
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Madonna performs during the halftime show for Super Bowl XLVI in Indianapolis on Feb. 5, 2012. During the act, British singer M.I.A. gave the finger to the audience, reportedly upsetting Madonna.
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The Material Girl stops by The Tonight Show with Jay Leno on Jan. 30, 2012 for an interview.
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Madonna poses with her Golden Globe award for best original song in a motion picture on Jan. 15, 2012. She won for the song "Masterpiece," which appears in her movie, "W.E." The song was not eligible for an Oscar because it was the second, rather than first, song heard during the film's closing credits.
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Madonna, right, arrives with her boyfriend Braihim Zaibat, in scarf, at London's Heathrow airport on her birthday, Tuesday, Aug. 16, 2011. The 53-year-old singer's children are also in tow, including David Banda, second from right, Mercy Ritchie, in white shirt, and Lourdes Ciccone Leon, far left.
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Oprah Winfrey speaks with Tom Hanks, left, and Madonna on stage during the taping of the third to last "Oprah Winfrey Show" at the United Center in Chicago on May 17, 2011.
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Lourdes, left, and Madonna arrive at the Vanity Fair Oscar party at Sunset Tower in West Hollywood, Calif., on Feb. 27, 2011.
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Madonna poses during the opening of her gym called Hard Candy Fitness in Mexico City on Nov. 29, 2010.
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Madonna holds her daughter Mercy James, who was adopted from Malawi, during a visit to that country's Gumulira village on Monday, April 5, 2010. Madonna is in the country on a charity tour and is starting a girls' academy there.
Madonna joins Larry David, left, and Ricky Gervais on an episode of "The Marriage Ref" in March 2010. They discussed the case of a couple who were fighting over possessions left from past relationships.
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Madonna and daughters Lourdes and Mercy James, as well as boyfriend Jesus Luz, watch a samba school perform in a parade in Rio de Janeiro on Feb. 14, 2010.
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Madonna performs at the "Hope For Haiti Now: A Global Benefit For Earthquake Relief" event in New York City on Jan. 22, 2010.
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Madonna performs during her "Sticky & Sweet" tour in Barcelona, Spain, on Tuesday, July 21, 2009. It's her eighth concert tour, and is the highest grossing tour by a solo artist.
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On Sunday, July 19, Madonna visited some of the eight workers injured when a stage set for her tour collapsed in Marseille, France. Two men were killed in the accident.
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Madonna holds 3-year-old Chifundo "Mercy" James in an undated photo. In June 2009, Malawi 's highest court overruled a lower court, saying the singer can adopt the girl.
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Madonna and son, David Banda, visit the Mphandula Child Care Centre, built by Madonna's charity, Raising Malawi, in Lilongwe, Malawi. The singer adopted David from the African country in 2009 and is in the process of adopting a daughter from the country.
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Madonna is watched by local children during a visit to Chinkhota village near Lilongwe, Malawi, on Sunday, March 29, 2009.
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Madonna and model Jesus Luz are seen on the streets of Manhattan on March 1, 2009. Reports suggested the pop star and the Brazilian model became an item during a steamy shoot for W magazine after her marriage to Guy Ritchie fell apart. In July 2009, they reportedly broke up.
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Madonna performs at the Pepsi Center -- her first performance ever in Denver -- as part of the North American leg of her "Sticky & Sweet" tour on Nov. 11, 2008.
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Madonna and her then-husband Guy Ritchie arrive at the festival palace for the gala screening of director Steven Soderbergh's film "Che" at the Cannes Film Festival on Wednesday, May 21, 2008, in Cannes, France. The couple was dogged by rumors throughout the summer that their marriage of almost eight years was on the rocks and that Madonna was having an affair with baseball star Alex Rodriguez. By fall the rumors of a split were confirmed and the first phase of the couple's divorce became official on Nov. 21, 2008.
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Madonna is joined by Justin Timberlake for a duet during a performance to celebrate the release of her new CD "Hard Candy" at Roseland Ballroom on Wednesday, April 30, 2008, in New York.
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Madonna embraces her daughter Lourdes, 9, left, son Rocco, 6, right, and David Banda, 13 months, whom she adopted with her husband Guy Ritchie. Madonna said that David is healthy and thriving in her London home, in an interview that aired Wednesday, Oct. 25, 2006, on "The Oprah Winfrey Show."
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Madonna strikes a pose during The Re-Invention Tour in 2004, complete with a red string around her wrist, a custom associated with Judaism's Kabbalah. Since the late 1990s, Madonna has been a devotee of the religion.
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In 2003, Madonna released her first children's book, "The English Roses." Her latest fable, "Lotsa de Casha," illustrates that money can't buy love or guarantee happiness.
Madonna performs at the first London concert of her "Confessions" world tour at Wembley Arena in 2006. Once again, the singer ignited controversy with her use of religious symbols, such as the crucifix and crown of thorns, during her performance.
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Madonna sings her dance single "Hung Up" from her tenth album, "Confessions on a Dance Floor," at the 12th annual MTV Europe Music Awards in Lisbon, Portugal.
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Britney Spears, left, and Madonna kiss during the opening performance of the MTV Video Music Awards at New York's Radio City Music Hall on Thursday, Aug. 28, 2003. The two pop princesses sang "Like A Virgin" in white wedding dresses, mimicking Madonna's performance during the inaugural show in 1984.
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Madonna jams on a guitar while wearing a Scottish kilt during the "Drowned" World Tour 2001. The tour was Madonna's first in eight years, following her 1993 "The Girlie Show" tour.
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Madonna gave birth to her son, Rocco John Ritchie, on Aug. 11, 2000. Later that year, she married Rocco's father, Guy Ritchie, whom she met in 1999 through mutual friends Sting and his wife, Trudie Styler.
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Madonna's critically acclaimed 1998 album, "Ray of Light," featured personal lyrics about motherhood, fame and spirituality. Produced by William Orbit, the music was heavily influenced by electronica, techno and trip-hop.
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After much campaigning, Madonna landed the role of Eva Peron in the film adaptation of Andrew Lloyd Webber's musical, "Evita," in 1996. She won a Golden Globe award for Best Actress in a Musical or Comedy for her portrayal. The singer was pregnant with her first child, Lourdes Maria (Lola) Ciccone Leon, during filming.
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In 1993, Madonna hit the road on "The Girlie Show" tour in support of her sexually charged album, "Erotica." Along with the album, the singer released "Sex," a soft-core pornographic book that featured erotic photographs of herself, models and other celebrities.
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In April 1990, Madonna began her year-long Blonde Ambition tour, which featured the dance-club favorite "Vogue," and the infamous cone bras. The tour's successful documentary, "Truth or Dare," was released the following year.
Madonna's fourth album, "Like a Prayer," sparked controversy due to the title track's 1989 music video, which combined religious and sexual imagery.
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Sean Penn and Madonna began dating in 1985 and married later that year on the singer's 27th birthday. The marriage lasted less than four years.
In 1985, Madonna starred in the romantic comedy "Desperately Seeking Susan," along with Rosanna Arquette. The singer-turned-actress received positive reviews from critics for her performance. "If there's any moment in my career that I'm the most fond of, I would say it's the beginning," she told NBC's TODAY. "You don't have any preconceived notions and any kind of cynicism. You're totally naive, pure, innocent."
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This provocative song was the pop star's first No. 1 single, topping the charts in 1984 and 1985. Madonna's memorable performance of "Like a Virgin" at the first MTV Video Music Awards featured her writhing on stage wearing a wedding gown.
Raised in a Catholic family in the Detroit suburbs, Madonna suffered tragedy at an early age when her mother died of breast cancer in 1963, when Madonna was just 5. She told NBC's Meredith Vieira, "Because of it, I'll always have an affinity and connection for children who have lost their mothers."