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By Erik Ortiz and Ali Gostanian

At least two people were killed overnight Wednesday in an apparent road rage attack across western Oklahoma that involved multiple cars, authorities said.

The first calls came in at about 11:35 p.m. local time in Canadian County, west of Oklahoma City, with reports of a shooting on Interstate 40. As the vehicle traveled westbound through two more counties, multiple shots were fired at numerous cars, Custer County Sheriff Bruce Peoples told NBC News.

Related: Suspect in Road-Rage Killing of Child Indicted

At least one person was killed in Caddo County, and the second in neighboring Custer County, Peoples added. The victims were not immediately identified.

A suspect was chased by the Oklahoma Highway Patrol for about 45 miles. The gunman — an unidentified male driver — was arrested early Thursday without incident in Custer County, and was being held in the county jail, authorities said.

The Oklahoma State Bureau of Investigation is handling the case.

This is a developing story. Please refresh for updates.