Biden will be in the U.K. to take part in the Group of Seven summit of world leaders in Carbis Bay, a small seaside resort in Cornwall, around 300 miles west of London. The meeting will run June 11 to 13.
Leaders from Germany, France and Japan will also attend the summit where climate change and Covid-19 recovery are set to be high on the agenda.
The coronavirus pandemic has limited opportunities for Biden to travel outside of the U.S. so the G7 gathering will be his first foreign engagement in person.
The meeting will be a significant event for the royal, following the death in April of her husband, Prince Philip, although she has made several public appearances since then.
The Bidens sent their condolences following Philip's death and said they were keeping the royal family "in our hearts during this time."
Elizabeth, 95, the world's longest-reigning living monarch, has met with all American presidents since 1951, apart from President Lyndon B. Johnson, and next year she will mark 70 years on the throne, known in Britain as the platinum jubilee.
Planning has already begun for a four-day celebration in June 2022, including an extra national holiday, events across the Commonwealth, as well as "events that mix the best of British ceremonial splendor and pageantry with cutting-edge artistic and technological displays."
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The queen met Biden's predecessor, Donald Trump, in 2018 and hosted him again during a formal state visit to the U.K. in June 2019.